Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features.
Kwakye, Gunnar F.; Paoliello, Monica M. B.; Mukhopadhyay, Somshuvra; Bowman, Aaron B.; Aschner, Michael
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 12 (7):7519-7540; 10.3390/ijerph120707519 JUL 2015. Open access article at PubMed Central.
Partial abstract:
Kwakye, Gunnar F.; Paoliello, Monica M. B.; Mukhopadhyay, Somshuvra; Bowman, Aaron B.; Aschner, Michael
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 12 (7):7519-7540; 10.3390/ijerph120707519 JUL 2015. Open access article at PubMed Central.
Partial abstract:
[This] review discusses the advances made in understanding the essentiality and neurotoxicity of Manganese (Mn). We review occupational Mn-induced parkinsonism and the dynamic modes of Mn transport in biological systems, as well as the detection and pharmacokinetic modeling of Mn trafficking. In addition, we review some of the shared similarities, pathologic and clinical distinctions between Mn-induced parkinsonism and Parkinson's disease. Where possible, we review the influence of Mn toxicity on dopamine, gamma aminobutyric acid (GABA), and glutamate neurotransmitter levels and function. We conclude with a survey of the preventive and treatment strategies for manganism and idiopathic Parkinson's disease.
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