Wednesday, August 08, 2018

Jordan Price and students publish in Journal of Bacteriology

New publication by Jordan Price, Assistant Professor of Biology, with students Kallie Jiang and Abby Galantowicz, and collaborators at Univ Calif Berkeley:

Price, Jordan V.; Jiang, Kallie; Galantowicz, Abby; Freifeld, A., & Vance, R. E. (2018). Legionella pneumophila is directly sensitive to 2-deoxyglucose-phosphate via its UhpC transporter but is indifferent to shifts in host cell glycolytic metabolism. Journal of Bacteriology, 200(16), 176. doi:10.1128/JB.00176-18 ER
Importance of this research:  "We explored the relationship between macrophage glycolysis and replication of an intracellular bacterial pathogen, Legionella pneumophila. Previous studies demonstrated that a glycolysis inhibitor, 2-deoxyglucose (2DG), blocks replication of L. pneumophila during infection of macrophages, leading to speculation that L. pneumophila may exploit macrophage glycolysis. We isolated L. pneumophila mutants resistant to the inhibitory effect of 2DG in macrophages, identifying a L. pneumophila hexose-phosphate transporter, UhpC, that is required for bacterial sensitivity to 2DG during infection. Our results reveal how a bacterial transporter mediates the direct antimicrobial effect of a toxic metabolite. Moreover, our results indicate that neither induction nor impairment of host glycolysis inhibits intracellular replication of L. pneumophila, which is consistent with a view of L. pneumophila as a metabolic generalist."

Monday, August 06, 2018

New publications by Stinebring (Physics & Astronomy) and Moore (Biology)

Recent publications by Dan Stinebring, Francis D Federighi Professor of Physics; and Mike Moore, Professor of Biology:

Lam, M. T., Ellis, J. A., Grillo, G., Jones, M. L., Hazboun, … Daniel R. Stinebring, et al. (2018). A second chromatic timing event of interstellar origin toward PSR J1713+0747. Astrophysical Journal, 861(2), 132. 10.3847/1538-4357/aac770 ER

an Open Access journal
from Taylor & Francis
Zhu, Z., Wang, J., Cai, Y., Zhao, K., Michael J. Moore, & Wang, H. (2018). Complete plastome sequence of erythropalum scandens (erythropalaceae), an edible and medicinally important liana in china. Mitochondrial Dna Part B-Resources, 3(1), 139-140. 10.1080/23802359.2017.1413435 ER