Thursday, February 27, 2020

Student Janet Wu publishes in Science Translational Medicine

We were excited to learn that 4th-year student Janet Wu is a co-author on a paper published this week in Science Translational Medicine:
Wnt-mediated endothelial transformation into mesenchymal stem cell–like cells induces chemoresistance in glioblastoma.

Authors: Menggui Huang, Duo Zhang, Janet Y. Wu, Kun Xing, Euin Yeo, Chunsheng Li, Lin Zhang, Eric Holland, Lutian Yao, Ling Qin, Zev A. Binder, Donald M. O'Rourke, Steven Brem, Constantinos Koumenis, Yanqing Gong, Yi Fan.

Science Translational Medicine, 26 Feb 2020, Vol. 12, Issue 532, eaay7522
DOI: 10.1126/scitranslmed.aay7522

The paper stems from research at the Univ. of Pennsylvania Perelman School of Medicine, and suggests a strategy to overcome therapeutic resistance in Glioblastoma, one of the most aggressive brain tumors.  

Science Translational Medicine is one of the suite of Science journals published by AAAS.

Thursday, February 06, 2020

Aaron Goldman and collaborators publish in Origins of Life and Evolution of Biospheres

New publication from Associate Professor of Biology Aaron Goldman, as cited in Web of Science:
"Reactivity of Metabolic Intermediates and Cofactor Stability under Model Early Earth Conditions."
Authors: Maltais, TR; VanderVelde, D; LaRowe, DE; Goldman, AD; Barge, LM.
Origins of Life and Evolution of Biospheres access via SpringerLink for subscribers  Published online: 25 JAN 2020

From the conclusion: This research suggests "that perhaps early Earth’s oxygen-free atmosphere and ocean would be a critical factor for stabilizing some of these metabolic intermediates long enough (and suppressing side reactions) for proto-metabolic reactions to occur. Further investigations of cofactors with minerals could assist to overcome the competing chemistries, and further define the capabilities of cofactor chemistry in the early Earth environment."