Tuesday, July 05, 2016

Citral shown to decrease cancer cell proliferation (new publication from R.J. Whelan)

New article from Rebecca Whelan, Associate Professor, Department of Chemistry and Biochemistry:

Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation.

Kapur, Arvinder; Felder, Mildred; Fass, Lucas; Kaur, Justanjot; Czarnecki, Austin; Rathi, Kavya; Zeng, San; Osowski, Kathryn Kalady; Howell, Colin; Xiong, May P.; Whelan, Rebecca J.; Patankar, Manish S.

Scientific Reports, published online June 8 2016,  Article number 27530.  Open access at PubMedCentral.

Partial abstract:
"The monoterpenoid, citral, when delivered through PEG-b-PCL nanoparticles inhibits in vivo growth of 4T1 breast tumors. Here, we show that citral inhibits proliferation of multiple human cancer cell lines. ...This study indicates that citral in PEG-b-PCL nanoparticle formulation should be considered for treatment of breast and other tumors."

More about Scientific Reports, a NatureResearch Journal.

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