Friday, October 20, 2017

Estrogens and the Cognitive Symptoms of Schizophrenia

New publication from Professor of Neuroscience Jan Thornton:

McGregor, Claire, Alexander Riordan, and Janice Thornton. "Estrogens and the Cognitive Symptoms of Schizophrenia: Possible Neuroprotective Mechanisms." Frontiers in Neuroendocrinology, vol. 47, 2017, pp. 19-33, doi:10.1016/j.yfrne.2017.06.003.

From the abstract: "We review the relationship between estrogens and brain derived neurotrophic factor, neuroinflammation, NMDA receptors, GABA receptors, and luteinizing hormone. Exploring these pathways may enable novel treatments for schizophrenia and a greater understanding of this devastating disease."

https://www.journals.elsevier.com/frontiers-in-neuroendocrinology

Thursday, September 28, 2017

Translating Science Symposium, Friday September 29

The libraries have been highlighting science journalism, science writing, and science media all week long, to promote the symposium happening tomorrow.  Take a look at the science library tumblr and the main library twitter #translatingsciencesymopsium - so many good resources to feature, one week certainly can't do justice to the abundance of great science writing available online and in print.

Here is one more recommendation that can't fail to please: The Best American Science and Nature Writing, an annual series that can be found in the science library.  Check out a volume!
http://www.hmhco.com/at-home/featured-shops/popular-series/best-american-series/ba-science-nature

Published by HMH LOGO

Tuesday, September 12, 2017

New faculty publications from Mike Moore (Biology) and Lisa Ryno (Chemistry)

New publications from Michael Moore and Lisa Ryno, as found in the Web of Science.

Guo, Rui, Jacob B. Landis, Michael J. Moore, Aiping Meng, Shuguang Jian, Xiaohong Yao, and Hengchang Wang. 2017. Development and application of transcriptome-derived microsatellites in actinidia eriantha (actinidiaceae). Frontiers in Plant Science 8: 1383.

Ryno, Lisa M., Emma R. Brezel, Sarel J. Loewus, and Erica J. Zheng. 2017. Targeting sigma factor controlled signaling pathways to modulate biofilm growth and composition. FASEB Journal 31, 939.5 (conference presentation).

Sun, Yanxia, Michael J. Moore, Nan Lin, Kole F. Adelalu, Aiping Meng, Shuguang Jian, Linsen Yang, Jianqiang Li, and Hengchang Wang. 2017. Complete plastome sequencing of both living species of circaeasteraceae (ranunculales) reveals unusual rearrangements and the loss of the ndh gene family. BMC Genomics 18: 592.

Zheng, Erica J., Eric W. Bell, and Lisa M. Ryno. 2017. Exploring inhibitors of the periplasmic chaperone SurA using fluorescence anisotropy. FASEB Journal 31, 939.4 (conference presentation)

Thursday, July 27, 2017

Kwakye on dopaminergic cell model of Parkinson's; Moore publishes on carnivorous caryophyllales


New publications from Gunner Kwakye, Neuroscience and Michael Moore, Biology. Student co-authors (now alumni) include Weelic Chong, Jessica Jimenez and Jessica Mikenas.

Chong, Weelic, Jessica Jimenez, Matthew McIIvin, Mak A. Saito, and Gunnar F. Kwakye. 2017. Alpha-synuclein enhances cadmium uptake and neurotoxicity via oxidative stress and caspase activated cell death mechanisms in a dopaminergic cell model of Parkinson's disease. Neurotoxicity Research 32, no. 2: 231-246.  Online access for subscribers


http://www.amjbot.org/ 
Walker, Joseph F., Ya Yang, Michael J. Moore, Jessica Mikenas, Alfonso Timoneda, Samuel F. Brockington, and Stephen A. Smith. 2017. Widespread paleopolyploidy, gene tree conflict, and recalcitrant relationships among the carnivorous caryophyllales. American Journal of Botany 104, no. 6: 858-867.  Open Access article

Tuesday, July 18, 2017

Neuronal metal manganese effect on arginase activity implicated in Huntington's disease

Assistant Professor of Neuroscience Gunnar Kwakye is one of 22 collaborators in this research, from institutions in England, Illinois, Italy, Michigan, New York, Ohio, Pennsylvania, Tennessee and Texas.

Bichell TJV, Wegrzynowicz M, Tipps KG, Bradley EM, Uhouse MA, Bryan M, Horning K, Fisher N, Dudek K, Halbesma T, et al. 2017.

Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model. Biochimica Et Biophysica Acta-Molecular Basis of Disease 1863(6):1596-604

http://www.sciencedirect.com/science/journal/09254439
sciencedirect.com/science/journal/09254439
Huntington's disease (HD) is caused by a mutation in the huntingtin gene (HIT), resulting in profound striatal neurodegeneration through an unknown mechanism. Perturbations in the urea cycle have been reported in HD models and in HD patient blood and brain. In neurons, arginase is a central urea cycle enzyme, and the metal manganese (Mn) is an essential cofactor. Deficient biological responses to Mn, and reduced Mn accumulation have been observed in HD striatal mouse and cell models. Here we report in vivo and ex vivo evidence of a urea cycle metabolic phenotype in a prodromal HD mouse model. Further, either in vivo or in vitro Mn supplementation reverses the urea-cycle pathology by restoring arginase activity. We show that Arginase 2 (ARG2) is the arginase enzyme present in these mouse brain models, with ARG2 protein levels directly increased by Mn exposure. ARG2 protein is not Teduced in the prodromal stage, though enzyme activity is reduced, indicating that altered Mn bioavailability as a cofactor leads to the deficient enzymatic activity. These data support a hypothesis that mutant HIT leads to a selective deficiency of neuronal Mn at an early disease stage, contributing to HD striatal urea-cycle pathophysiology through an effect on arginase activity. (C) 2017 The Author(s). Published by Elsevier B.V.

Open Access at Sciencedirect

Thursday, July 13, 2017

"Web app for population viability and harvesting analyses." Co-authored by Rich Salter

New publication from Professor Emeritus Richard Salter:
Official Journal of the Resource Modeling Association

Getz WM, Muellerklein OC, Salter RM, Carlson CJ, Lyons AJ, Seidel DP. 2017. A web app for population viability and harvesting analyses. Natural Resource Modeling 30(2):e12120

Abstract:
Population viability analysis (PVA) is used to assess the probability that a biological population will persist for a specified period of time. Such models are typically cast as Markov processes that may include age, stage, sex and metapopulation structures, density-dependence and ecological interaction processes. They may also include harvesting, stocking, and thresholds that trigger interventions. Here we present a PVA web app that includes extensible user-selected options. Specifically, this PVA web app allows for the specification of one to ten age classes, one or two sexes, single population or metapopulation configurations with 2 or 3 subpopulations, as well as density-dependent settings for inducing region-specific carrying capacities. Movement among subpopulations can be influenced by age, metapopulation connectivity, and attractivity of regions based on the relative fitness of the youngest age classes in each region. Simulations can be carried out deterministically or stochastically, with a user-specified combination of demographic and environmental processes. This PVA web app is freely available at http://www.numerusinc.com/webapps/pva for running directly on any browser and device. It is easily modified by users familiar with the NovaModeler Software Platform.

Subscriber access on Wiley Online Library.

Friday, July 07, 2017

Oxidative stress and neurotoxicity in Huntington's disease: publication by G. Kwakye

About NeuroToxicology
New publication from Assistant Professor of Neuroscience Gunnar Kwakye and students in the Kwakye lab:

"Acute exposure to chlorpyrifos caused NADPH oxidase mediated oxidative stress and neurotoxicity in a striatal cell model of Huntington's disease."
Authors:
Gifty A. Dominah, OC'15.; Rachel A. McMinimy, OC'17; Sallay Kallon, OC'17; Gunnar F. Kwakye.
Source:
NeuroToxicology, vol. 60, pp 54-69;  MAY 2017

Subscriber Access on ScienceDirect
Abstract and indexing on PubMed
About NeuroToxicology