The Mehta lab recently published research on "the extent of spontaneous cocrystallization for 14 cocrystal systems, at four levels of humidity. [Their] results show cocrystal formation in all 14 systems to varying extent and are consistent with literature reports that higher humidity correlates with more rapid cocrystal formation."
Davies, Riley D. '19, Vigilante, Nicolas J. '18, Frederick, Aaron D. '16, Mandala, Venkata S. '15, Mehta, Manish A., Professor of Chemistry and Biochemistry. 2022. The effects of humidity on spontaneous cocrystallization: a survey of diacid cocrystals with caffeine, theophylline, and nicotinamide. Journal of Chemical Crystallography. DI 10.1007/s10870-022-00922-8. Early access, January 2022. Download at SpringerLink.For a bit of background on crystal engineering, see the article with that title by Roger Bishop in the Kirk-Othmer Encyclopedia of Chemical Technology, online.
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