Jordan Price, Dan Russo '19 publish in Mbio with five co-authors

Jordan Price, Assistant Professor of Biology, and Daniel Russo '19 co-authored a paper with researchers at University of California Berkeley and Duke University, published in mBio, an open-access journal from the American Society for Microbiology.

Price, J. V., Russo, D., Ji, D. X., Chavez, R. A., DiPeso, L., Lee, A. Y., Coers, J., & Vance, R. E. (2019). IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila. Mbio, 10(6), 2629.

https://mbio.asm.org/

From the abstract:
"Our study defines a complete set of cell-intrinsic factors required for IFN-􏰀-mediated restriction of an intracellular bacterial pathogen and highlights the combinatorial strategy used by hosts to block bacterial replication in macrophages...Our results clarify the molecular basis underlying the potent effects of IFN-􏰀 and highlight how redundancy downstream of IFN-􏰀 is key to prevent exploitation of macrophages by pathogens."