Tuesday, August 03, 2010

Whelan article in Tumor Biology on ovarian cancer biomarker

The most recent article published by a member of the science faculty, in collaboration with three undergraduate students, appears in Tumor Biology [online first].  Rebecca Whelan is Assistant Professor of Chemistry and Biochemistry.

Zach T. Berman, Lee J. Moore, Kathleen E. Knudson and Rebecca J. Whelan.  Synthesis and structural characterization of the peptide epitope of the ovarian cancer biomarker CA125 (MUC16).  Tumor Biology.  Published online Monday, June 21, 2010.    DOI  - 10.1007/s13277-010-0062-4
   http://www.springerlink.com/content/Q4740054V36410R6 [abstract and page 1 only are accessible to non-subscribers]

Whelan's research advances understanding of the structural characterization of CA125, particularly the amino acid sequence and oxidation state of the protein.  CA125 is acknowledged as the "best validated and most widely assayed biomarker" of ovarian cancer, and the "gold standard" against which other biomarkers are measured.  Understanding CA125 and its potential for simultaneous use with other biomarkers is an important step toward more reliable and earlier detection of ovarian cancer.

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Ovarian conservation post hysterectomy said...
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