Thursday, January 11, 2007

Novel Neuropeptides, Mass Spectrometry and Peptidomics in Analytical Chemistry, Jan. 1, 2007

Now on the science library's current journal display, and at the American Chemical Society publications site: Analytical Chemistry, Jan. 1, 2007:

MS applied to the discovery of novel peptides from the brain. Marcus Svensson, Karl Skold, Anna Nilson, Maria Falth, Katarina Nydahl, Per Svenningsson, and Per E. Andren.

"Per E. Andren and colleagues at Uppsala University and the Karolinska Institutet describe neuropeptidomics approaches in brain lysates and tissue section to study peptide expression in disease models and to identify potentially biological active neuropeptides."

The authors provide a helpful overview of neuropeptides (smallish proteins present throughout the nervous system) and the technology of visualizing and analyzing proteins with mass spectrometry. Wikipedia gives a handy definition of one of the techniques used by the researchers: MALDI MS.

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